Prealbumin (Transthyretin)
Prealbumin testing evaluates nutritional status, protein metabolism, and can help monitor recovery from illness or malnutrition.
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What this test measures
Prealbumin, also known as transthyretin (TTR), is a protein produced primarily in the liver that plays an important role in transporting thyroid hormones (thyroxine) and vitamin A through the bloodstream. The protein serves as a carrier for retinol-binding protein, which facilitates the transport of vitamin A throughout the body.
Prealbumin has a relatively short half-life of about 2 days, making it a useful indicator of recent changes in protein synthesis and nutritional status. Healthcare providers often use prealbumin testing to monitor nutritional health, especially in individuals who are seriously ill or hospitalized. Due to its short half-life, prealbumin is considered a more sensitive indicator of protein-energy status than albumin and serves as a better indicator of dietary protein intake rather than overall nutritional status.
Who should consider this test
You might consider this test if you are experiencing any of the following:
- Individuals with chronic illnesses that may affect nutritional status, such as liver disease, kidney disease, or inflammatory conditions.
- Patients recovering from surgery, trauma, or serious infections who need monitoring of their nutritional recovery.
- Those receiving total parenteral nutrition (IV feeding) or specialized nutritional support who require monitoring of protein metabolism.
- People with suspected malnutrition or protein-energy deficiency who need assessment of their nutritional status.
- Individuals with unexplained weight loss or poor appetite who may benefit from nutritional evaluation.
What to expect
Preparation
No special preparation is needed for this test. No fasting is required. Continue taking medications as prescribed unless your healthcare provider advises otherwise.
Sample Type
A healthcare professional will collect a blood sample from a vein in the arm using a small needle. The procedure typically takes less than five minutes.
Collection
During the blood draw, individuals may feel a slight sting when the needle is inserted. After collection, there may be minor soreness at the needle site, but this usually resolves quickly.
Turnaround
Results are typically available within 1-3 business days after the laboratory receives the sample.
Understanding your results
Normal prealbumin levels typically range between 15-40 mg/dL, though reference ranges may vary slightly between laboratories. Results should be interpreted by a healthcare provider in the context of overall health status and other clinical findings.
| Population | Reference Range | Notes |
|---|---|---|
| Adults | 15-40 mg/dL | Normal range for healthy adults |
| Adult Males | 20-50 mg/dL | May be slightly higher than females |
| Adult Females | 10-40 mg/dL | May be affected by pregnancy and hormonal changes |
Reference ranges may vary by laboratory and individual factors. Results should be interpreted by a healthcare provider in the context of your overall health.
What does a “Low” result mean?
Low prealbumin levels typically indicate a need for nutritional assessment and may suggest malnutrition, liver disease, inflammation, or tissue damage. Low levels can also occur with infection, inflammatory conditions, and trauma, and elderly individuals may be at increased risk for decreased prealbumin levels. Certain medications and pregnancy can also affect prealbumin levels.
What does a “High” result mean?
Elevated prealbumin levels may be associated with chronic kidney disease, steroid use, or alcoholism. Higher values have also been observed in certain conditions like Hodgkin's disease. However, elevated levels are less common and may require further evaluation to determine the underlying cause.
Privacy & confidentiality
Test results are confidential and protected under HIPAA regulations. Results are not shared with insurance companies or added to your permanent medical records unless you specifically request this. No doctor visit required for testing.
Frequently asked questions
Related tests
Albumin
$29Often tested together to provide comprehensive protein status assessment
View TestC-Reactive Protein (CRP)
$49Helps interpret prealbumin results by identifying inflammation that may affect levels
View TestLiver Function Panel
$39Evaluates liver health since prealbumin is produced in the liver
View TestBasic Thyroid Panel
$59Prealbumin transports thyroid hormones, so thyroid function may be relevant
View TestRelated conditions
CPT Code: 84134
This test may not be available in: NY, NJ, RI
This page is for informational purposes only and does not constitute medical advice. Always consult with a healthcare provider regarding any health concerns. LevelPanel does not diagnose, treat, or prescribe.
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Not sure if this is the right test? Contact our care team for guidance.